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Wednesday 01 November 2000

Randomised, prospective, controlled trial comparing tropisetron with metoclopramide and placebo in controlling postoperative nausea and vomiting.

By: Muhammad SR, Abbas SZ, Abbas SQ.

J Pak Med Assoc 2000 Nov;50(11):386-8

OBJECTIVE: To compare the results of Tropisetron, Metoclopramide and placebo on postoperative nausea and vomiting in patients undergoing minilaparotomy cholecystectomy. SETTING: Patients operated for minilaparotomy cholecystectomy in two private hospitals in Karachi. SUBJECTS: Fifty consecutive patients of all ages and both sex who had simple cholelithiasis and underwent minilaparotomy cholecystectomy by a single surgeon. MAIN OUTCOME MEASURES: Postoperative nausea and vomiting (PONV) at 2 hours and within 24 hours and requirement of rescue antiemetic. RESULTS: Tropisetron was better than Metoclopramide and placebo in controlling postoperative nausea and vomiting. CONCLUSION: Tropisetron when given at induction at a dose of 2 mg. intravenously prevents PONV better than Metoclopramide and placebo in 2 hours and 24 hours. It also reduces the need for rescue antiemetic significantly.

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