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Tuesday 18 September 2007

[Prophylactic effect of tropisetron hydrochloride against nausea and vomiting in patients receiving chemotherapy for hematological malignancies]

By: Nomura K, Fujimoto Y, Taniguchi K, Shimizu D, Okamoto M, Shimura K, Matsumoto Y, Kanbayashi Y, Tanaka S, Kaneko H, Horiike S, Shimazaki C, Yokota S, Taniwaki M.

Gan To Kagaku Ryoho 2007 Sep;34(9):1513-5

To establish the effectiveness of oral 5-HT(3) antagonist, oral 5 mg tropisetron was introduced in the 21 cases with hematological malignancies for the prevention of chemotherapy-induced nausea and vomiting. Nausea and vomiting did not develop in 81% of patients receiving the tropisetron in this study. The results suggested that oral tropisetron is effective for the control of acute, and to a lesser extent, delayed, nausea and vomiting. The drug enhanced patients' quality of life and reduced the clinical cost. In conclusion, tropisetron is effective for the prevention of chemotherapy-induced nausea and vomiting in treatment for hematological malignancies. It is suitable as first-line therapy for outpatients.

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